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Wednesday, May 13, 2020 | History

1 edition of Short protocols in pharmacology and drug discovery found in the catalog.

Short protocols in pharmacology and drug discovery

S. J. Enna

Short protocols in pharmacology and drug discovery

a compendium of mehods from current protocols in Pharmacology

by S. J. Enna

  • 276 Want to read
  • 7 Currently reading

Published by J. Wiley & Sons in Hoboken .
Written in English


Edition Notes

Includes bibliographical references and index.

Statementeditorial board, S.J. Enna (editor-in-chief), Michael Williams (editor-in-chief) ; John W. Ferkany, Terry Kenakin, Roger D. Porsolt
Classifications
LC ClassificationsRM301.25 .S49 2007
The Physical Object
Pagination1 v. (various pagings) :
ID Numbers
Open LibraryOL24518902M
ISBN 100470095261
ISBN 109780470095263
LC Control Number2006033930

DISCOVERY. CLINICAL DEVELOPMENT. PRE. CLINICAL. DEVELOPMENT. P h a s e 1. P h a s e 2. P h a s e 3. POST. APPROVAL. PHASE. Initial IND Desirable Clinical Pharmacology Properties of a Drug.   INTRODUCTION. A number of drug discovery and development programs have been hampered by issues with drug induced cardiac arrhythmia. This is particularly well-known for histamine receptor antagonists, e.g., the potent human ether-à-gogo-related gene (hERG) channel blocker Terfenadine (Teldane ®, Seldane ®).Terfenadine is an H1 receptor antagonist that was launched in Cited by:

Due to the failing “one-drug-fits-all” model, it has become increasingly necessary to develop personalized medicine that treats whole systems and brings the right drug to the right patient with the right dosages. In Systems Biology in Drug Discovery and Development: Methods and Protocols, leading. In in vivo pharmacology there are many factors that can confound the results obtained, if not taken adequately into consideration while study protocols are developed and executed. Claassen () in his book “Neglected factors in pharmacology and neuroscience research” highlighted many of these important by: 1.

This Special Issue of Molecules aims to provide a comprehensive look at the natural molecules in drug discovery and pharmacology, and will focus on the isolation and structure elucidation of new natural products, the mechanism of action, and the structure–function of natural products and their analogues, including but not limited to, the. Drug Information (from ) -- Information about thousands of prescription and over-the-counter drugs, herbs, and supplements, collected from the American Society of Health-System Pharmacists (ASHP) and the United States Pharmacopeia (USP).. Drug Therapy (from ) -- Explanations of topics such as antidepressants, blood thinners, chemotherapy, over-the-counter.


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Short protocols in pharmacology and drug discovery by S. J. Enna Download PDF EPUB FB2

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Short Protocols in Pharmacology and Drug Discovery provides condensed descriptions of more than methods compiled from the successful title Current Protocols in Pharmacology. Short Protocols in Pharmacology and Drug Discovery Contents Preface Contributors Chapter 1: Introduction to Drug Discovery and Development Overview of Drug Discovery and Development Introduction Pharmacology Medicinal Chemistry Drug Discovery Drug Targets Lead Discovery Compound Sources Biologicals, Antisense, and RNA Interference Computational Chemistry High-Throughput Screening Hit-to-Lead Lead Optimization Structure-Activity Relationships (SAR) Drug Metabolism.

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Auflage, 02//Pb. Experimental Pharmacology and Drug Discovery aims to publish significant basic research findings in pharmacology that shed light on mechanisms of drug action by analyzing the interaction with receptors and/or other specific biological targets, including enzymes, ion channels, transporters, transcription factors, etc The study of drug-biomolecule interaction includes analysis of binding.

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Acute, subacute and chronic studies: Protocols, objectives, methods of execution and regulatory - requirements. b. Reproductive toxicology assessment: Male reproductive toxicity, spermatogenesis, risk assessment in Pharmacology, antibodies.Discovery.

Development. Orientation: Clinical Development of a New Drug. Target selection (TS) Lead generation (LG) and optimisation (LO) Candidate drug (CD) prenomination.

Good Laboratory Practice (GLP) Toxicology Phase. Phase II: Early patient studies, tolerance, kinetics, pharmacology, efficacy (proof of concept), dose range, drug File Size: 1MB.Frontiers in Pharmacology is a member of the Committee on Publication Ethics.

Frontiers in Pharmacology generally endorses the relevant principles described in the 4 pillars of ethnopharmacology for all studies involving natural products submitted to all specialty sections in the journal. Similarly, the journal generally endorses protocols including a minimum of 2 cell-lines in vitro .